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活性蛋白
- Recombinant Human Mesothelin(MSLN),partial (Active)
- 恒遠生物蛋白表達平臺建立了從原核到真核四大重組表達系統(tǒng),并建立無細胞表達系統(tǒng),擁有基于昆蟲病毒外膜蛋白展示的蛋白表達技術(shù)、膜蛋白表達技術(shù)等一系列蛋白表達及純化技術(shù),有能力制備各種高難度蛋白。
Recombinant Human Mesothelin(MSLN),partial (Active)
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貨號：HYB-10154
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規(guī)格：
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圖片：
產(chǎn)品詳情
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純度：Greater than 92% as determined by SDS-PAGE.
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內(nèi)毒素：Less than 1.0 EU/ug as determined by LAL method.
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生物活性：Measured by its binding ability in a functional ELISA. Immobilized MSLN at 2 μg/ml can bind Anti-MSLN rabbit monoclonal antibody, the EC50 of the MSLN protein is 2.657-3.177 ng/ml.
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基因名：MSLN
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Uniprot No.：
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別名：CAK 1; CAK1; CAK1 antigen; cleaved form; Megakaryocyte potentiating factor ; Mesothelin; Mesothelin isoform 1 precursor ; MPF; Msln; MSLN_HUMAN; Pre pro megakaryocyte potentiating factor; Pre-pro-megakaryocyte-potentiating factor; SMR; SMRP; Soluble MPF mesothelin related protein
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分子結(jié)構(gòu)：
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種屬：Homo sapiens (Human)
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蛋白長度：Partial
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來源：Mammalian cell
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分子量：59.6 kDa
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表達區(qū)域：296-580aa
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氨基酸序列EVEKTACPSGKKAREIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLDVLKHKLDELYPQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQVATLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQLDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVLPLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQG
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蛋白標(biāo)簽：N-terminal hFc-tagged
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產(chǎn)品提供形式：Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
緩沖液：Lyophilized from a 0.2 μm filtered PBS, 6% Trehalose, pH 7.4
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儲存條件：Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質(zhì)期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
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產(chǎn)品描述：
The Recombinant Human Mesothelin MSLN is derived from mammalian cells with purity over 92% on SDS-PAGE. It contains AA Glu296-Gly580 and the molecular weight of this domain is 59.6kDa, and a human IgG1 Fc tag was fused at N-terminus.
Recombinant Human Mesothelin is valuable in cancer research as a target for therapy. It is also used for detecting anti-MLSN antibodies in functional ELISA.
Mesothelin is widely expressed in normal mesothelial cells, oncogenic mesothelial cells, and ovarian cancer cells. Faulty expression of MSLN plays a role in the multiplication and invasion of tumors.
When it is overexpressed, mesothelin may induce MAPK, PI3K, and NF-kB pathways. The induction of these pathways plays a part in the metastasis, proliferation, and survival of cancerous cells. Mesothelin also interacts with CA125 to facilitate the implantation of ovarian cancer cells in the peritoneum and the migration of carcinogenic pancreas cells by altering cellular adhesion. -
Datasheet & COA：Please contact us to get it.
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